Neutrophil Percentage to Albumin Ratio was Associated with Clinical Outcomes in Coronary Care Unit Patients

Background: Neutrophil percentage to albumin ratio (NPAR) has been shown be correlated with the prognosis of various diseases. This study aimed explore effect NPAR on patients in coronary care units (CCU). Method: All data this were extracted from Medical Information Mart for Intensive Care III (MIMIC-III, version1.4) database. divided into four groups according their quartiles. The primary outcome was in-hospital mortality. Secondary outcomes 30-day mortality, 365-day length CCU stay, hospital acute kidney injury (AKI), and continuous renal replacement therapy (CRRT). A multivariate binary logistic regression analysis performed confirm independent effects NPAR. Cox analyze association between curve line overall trend drawn by local weighted (Lowess). Subgroup used determine mortality different subgroups. Receiver operating characteristic (ROC) curves evaluate ability predict Kaplan–Meier constructed compare cumulative survival rates among groups. Result: total 2364 enrolled study. rate increased significantly as quartiles (p < 0.001). In analysis, independently associated (quartile 4 versus quartile 1: odds [OR], 95% confidence interval [CI]: 1.83, 1.20–2.79, p = 0.005, <0.001). OR, CI: 1.62, 1.16–2.28, Lowess showed a positive relationship moderate demonstrated through ROC curves. area under (AUC) 0.653 0.001), which is better than that platelet lymphocyte (PLR) 0.001) neutrophil count but lower Sequential Organ Failure Assessment 0.046) Simplified Acute Physiology Score II did not reveal any obvious interactions most However, increased, (log-rank, decreased significantly. also AKI 1.57, 1.19–2.07, 0.002, stay prolonged higher Conclusions: an risk factor